What question did this study set out to answer?

This research aims to explore the relationship between the structure of ATCUN-based Cu(II) complexes and their biological activities, particularly in DNA interaction and ROS generation.

May 16, 2026Open Access

Structure-Activity Relationships of ATCUN-Based Cu(II) Complexes with Large Chelate Rings: Interplay of ROS Generation, DNA Binding, and Nuclease Activity

Key Points

This research aims to explore the relationship between the structure of ATCUN-based Cu(II) complexes and their biological activities, particularly in DNA interaction and ROS generation.
Evaluated various Cu(II) ATCUN derivatives.
Assessed their DNA binding affinity and nuclease activity.
Measured levels of reactive oxygen species (ROS) generation.
Certain Cu(II) complexes showed enhanced DNA cleavage activity compared to the simplest GGH complex.
ROS generation was significantly increased by specific Cu(II) complexes, correlating with nucleolytic activity.

Abstract

Since the discovery of DNA cleavage and anticancer activity of the simplest Cu(II) ATCUN complex (peptide ligand: Gly-Gly-His, GGH) in 1983, systematic biological enhancements by derivatives have not been achieved....

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