Structure-Activity Relationships of ATCUN-Based Cu(II) Complexes with Large Chelate Rings: Interplay of ROS Generation, DNA Binding, and Nuclease Activity

Julian Heinrich; Johanna Lück; Dmitrii Varlakhanov; Ravi Kumar; Matthias Stein; Nora Kulak

doi:10.1039/d6dt00630b

January 1, 2026Dalton TransactionsOpen Access

Structure-Activity Relationships of ATCUN-Based Cu(II) Complexes with Large Chelate Rings: Interplay of ROS Generation, DNA Binding, and Nuclease Activity

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Key Points

This research aims to explore the relationship between the structure of ATCUN-based Cu(II) complexes and their biological activities, particularly in DNA interaction and ROS generation.
Evaluated various Cu(II) ATCUN derivatives.
Assessed their DNA binding affinity and nuclease activity.
Measured levels of reactive oxygen species (ROS) generation.
Certain Cu(II) complexes showed enhanced DNA cleavage activity compared to the simplest GGH complex.
ROS generation was significantly increased by specific Cu(II) complexes, correlating with nucleolytic activity.

Implication

Investigates the effects of Cu(II) ATCUN complexes on DNA interaction and ROS in cancer cells, indicating potential treatments.

Abstract

Since the discovery of DNA cleavage and anticancer activity of the simplest Cu(II) ATCUN complex (peptide ligand: Gly-Gly-His, GGH) in 1983, systematic biological enhancements by derivatives have not been achieved....

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Cite This Study

Heinrich et al. (2026) studied this question.

synapsesocial.com/papers/6a080acea487c87a6a40cc72 https://doi.org/10.1039/d6dt00630b

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Structure-Activity Relationships of ATCUN-Based Cu(II) Complexes with Large Chelate Rings: Interplay of ROS Generation, DNA Binding, and Nuclease Activity

Key Points

Implication

Abstract

Discussion

Cite This Study

Structure-Activity Relationships of ATCUN-Based Cu(II) Complexes with Large Chelate Rings: Interplay of ROS Generation, DNA Binding, and Nuclease Activity

Key Points

Implication

Abstract

Discussion

Cite This Study

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