An elevated TyG index (highest vs. lowest tertile) was independently associated with increased risks of all-cause death (HR 2.09; 95% CI 1.23-3.55), CV death, and MACCEs in patients with ADHF.
Cohort (n=932)
Does an elevated TyG index predict all-cause death, CV death, and MACCEs in patients with acute decompensated heart failure?
An elevated triglyceride glucose (TyG) index is an independent predictor of all-cause mortality, cardiovascular death, and MACCEs in patients hospitalized with acute decompensated heart failure.
Effect estimate: HR 2.09 (95% CI 1.23-3.55)
p-value: p=0.006
BACKGROUND: The triglyceride glucose (TyG) index has been proposed as a reliable marker of insulin resistance (IR) and an independent predictor of cardiovascular disease risk. However, its prognostic value in patients with acute decompensated heart failure (ADHF) remains unclear. METHODS: A total of 932 hospitalized patients with ADHF from January 1st, 2018 to February 1st, 2021 were included in this retrospective study. The TyG index was calculated as ln fasting triglyceride level (mg/dL) × fasting plasma glucose level (mg/dL)/2. Patients were divided into tertiles according to TyG index values. The primary endpoints were all-cause death, cardiovascular (CV) death and major adverse cardiac and cerebral events (MACCEs) during follow-up. We used multivariate adjusted Cox proportional hazard models and restricted cubic spline analysis to investigate the associations of the TyG index with primary endpoints. RESULTS: During a median follow-up time of 478 days, all-cause death, CV death and MACCEs occurred in 140 (15.0%), 103 (11.1%) and 443 (47.9%) cases, respectively. In multivariate Cox proportional hazard models, the risk of incident primary endpoints was associated with the highest TyG tertile. After adjustment for confounding factors, hazard ratios (HRs) for the highest tertile (TyG index ≥ 9.32) versus the lowest tertile (TyG index 9.08; CV death, TyG > 9.46; MACCEs, TyG > 9.87). CONCLUSIONS: The elevated TyG index was independently associated with poor prognosis, and thus would be useful in the risk stratification in patients with ADHF.
Huang et al. (Tue,) conducted a cohort in acute decompensated heart failure (ADHF) (n=932). Triglyceride glucose (TyG) index vs. Lowest TyG index tertile was evaluated on all-cause death, cardiovascular (CV) death and major adverse cardiac and cerebral events (MACCEs) (HR 2.09, 95% CI 1.23-3.55, p=0.006). An elevated TyG index (highest vs. lowest tertile) was independently associated with increased risks of all-cause death (HR 2.09; 95% CI 1.23-3.55), CV death, and MACCEs in patients with ADHF.