Key result
Elevated TyG index is linked to ~109% higher risk of death and MACCE in ADHF.
Why the study?
The prognostic value of the triglyceride glucose index, a marker of insulin resistance and cardiovascular risk, remains unclear in acute decompensated heart failure.
Does an elevated TyG index predict all-cause death, CV death, and MACCEs in patients with acute decompensated heart failure?
Population
932 hospitalized patients with ADHF
Comparison
Tertiles according to TyG index values
Design
Retrospective study
Follow-up
Median 478 days
Authors
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May inform ADHF risk stratification; hypothesis-generating and requires prospective validation.
Cohort (n=932)
Does an elevated TyG index predict all-cause death, CV death, and MACCEs in patients with acute decompensated heart failure?
Effect estimate: HR 2.09 (95% CI 1.23-3.55)
p-value: p=0.006
An elevated triglyceride glucose (TyG) index is an independent predictor of all-cause mortality, cardiovascular death, and MACCEs in patients hospitalized with acute decompensated heart failure.
Huang et al. (2022) conducted a cohort in acute decompensated heart failure (ADHF) (n=932). Triglyceride glucose (TyG) index vs. Lowest TyG index tertile was evaluated on all-cause death, cardiovascular (CV) death and major adverse cardiac and cerebral events (MACCEs) (HR 2.09, 95% CI 1.23-3.55, p=0.006). An elevated TyG index (highest vs. lowest tertile) was independently associated with increased risks of all-cause death (HR 2.09; 95% CI 1.23-3.55), CV death, and MACCEs in patients with ADHF.