ABSTRACT & FOUNDATIONAL SPECIFICATION This monograph presents the complete foundational specification of the Dimensional Priority and Semantic Override (DPSO) framework: a multi-scale, non-linear dynamical systems model of neurodivergence that bridges cellular mechanobiology, computational complexity, systems neuroscience, and sociological architectures. Reconceptualising neurodivergent phenotypes as emergent dynamical states arising from distinct strategies for precision allocation, executive control, and metabolic regulation within hierarchical predictive processing structures, this volume provides a continuous, unbroken derivation spanning from molecular receptor dynamics up to institutional systemic audits. This consolidated open-access deposition compiles the primary manuscript and its eleven supplementary companions into a single, comprehensive reference volume: • Primary Manuscript: Systems-level biological/cognitive architecture and oscillatory governance.• Supplement I: Structural decomposition of the autism gender gap and diagnostic pipeline epidemiology.• Supplement II: Formal theoretical extensions, cross-disciplinary derivations, and analytical validation.• Supplement III: Biophysical transduction, electrochemical shear stress hypothesis, and Piezo1-Calpain-2 synergy.• Supplement IV: Dynamical systems proofs for the binary processing bifurcation, SAT complexity scaling, and RL lock-in.• Supplement V: Neural implementation architecture, cholinergic grounding, and stochastic threshold dynamics.• Supplement VI: Resolution of four structural constraint axes (Admissibility Gate, metabolic context, and masking concurrency).• Supplement VII: Hemispheric lateralisation, interhemispheric gating, and the hardware basis of alexithymia/anhedonia.• Supplement VIII: Integrative mechanistic synthesis and cross-supplement unification of the complete cascade.• Supplement IX: The sociology of neurodivergence (UK structural audit of educational, clinical, and legal systems).• Supplement X: Functional, systemic, and neuroendocrine accommodation failure within institutional operational architecture.• Supplement XI: Formal resolution of fifteen structural challenge axes and specification of Level 4 empirical predictions. This monograph represents the complete foundational specification of the Dimensional Priority and Semantic Override (DPSO) framework—a multi-scale, non-linear dynamical systems model of neurodivergence bridging cellular mechanobiology, computational complexity, and sociological structures. By establishing numerous highly specific falsifiable empirical predictions, the framework is deposited as an open-access, expandable foundation for the scientific, clinical, and neurodivergent communities. The burden of downstream synthesis, clinical application, and empirical testing is intentionally deferred to the global intellectual commons, preserving the model’s status as a decentralized, open scientific architecture.
Sam Berry (Sat,) studied this question.
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