In 100 healthy controls, advancing age was associated with significant decreases in aortic systolic velocity and 3D wall shear stress, with 3D-WSS decreasing over up to 62% of the aorta surface area in the oldest cohort.
Cross-Sectional (n=100)
No
Healthy aortic hemodynamics measured by 4D-flow MRI are dependent on age and correlate with vessel diameter and cardiac function.
PURPOSE: To examine the effects of age, sex, and left ventricular global function on velocity, helicity, and 3D wall shear stress (3D-WSS) in the aorta of N = 100 healthy controls. METHODS: Fifty female and 50 male volunteers with no history of cardiovascular disease, with 10 volunteers per age group (18-30, 31-40, 41-50, 51-60, and 61-80 years) underwent aortic 4D-flow MRI. Quantification of systolic aortic peak velocity, helicity, and 3D-WSS distribution and the calculation of age group-averaged peak systolic velocity and 3D-WSS maps ("atlases") were computed. Age-related and sex-related changes in peak velocity, helicity, and 3D-WSS were computed and correlated with standard metrics of left ventricular function derived from short-axis cine MRI. RESULTS: No significant differences were found in peak systolic velocity or 3D-WSS based on sex except for the 18- to 30-year-old group (males 8% higher velocity volume and 3D-WSS surface area). Between successively older groups, systolic velocity decreased (13%, 0.35, P < .001). Arch and descending aorta systolic mean velocity, mean 3D-WSS, and median helicity increased with normalized left ventricular volumes: end diastolic volume (r = 0.31-0.37, P < .01), end systolic volume (r = 0.27-0.35, P < .01), and stroke volume (r = 0.28-0.35, P < .01). CONCLUSION: Healthy aortic hemodynamics are dependent on subject age, and correlate with vessel diameter and cardiac function.
Scott et al. (Wed,) conducted a cross-sectional in Healthy controls (n=100). Age and sex (Observational) was evaluated on Systolic velocity and 3D wall shear stress (3D-WSS). In 100 healthy controls, advancing age was associated with significant decreases in aortic systolic velocity and 3D wall shear stress, with 3D-WSS decreasing over up to 62% of the aorta surface area in the oldest cohort.
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