Key result
Advancing age linked to reduced aortic systolic velocity and 3D-WSS across ~62% of the aorta.
Why the study?
To examine the effects of age, sex, and left ventricular global function on velocity, helicity, and 3D wall shear stress in the aorta of healthy controls.
Population
100 healthy volunteers with no history of cardiovascular disease
Comparison
Hemodynamics across age groups, sex, and left ventricular function
Design
Cross-sectional study
Authors
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Supports age-adjusted aortic 4D-flow MRI norms; hypothesis-generating for links to clinical outcomes.
Cross-Sectional (n=100)
No
Healthy aortic hemodynamics measured by 4D-flow MRI are dependent on age and correlate with vessel diameter and cardiac function.
Scott et al. (2020) conducted a cross-sectional in Healthy controls (n=100). Age and sex (Observational) was evaluated on Systolic velocity and 3D wall shear stress (3D-WSS). In 100 healthy controls, advancing age was associated with significant decreases in aortic systolic velocity and 3D wall shear stress, with 3D-WSS decreasing over up to 62% of the aorta surface area in the oldest cohort.
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