Women exhibited greater age-associated increases in carotid stiffness, carotid pulse pressure, and cerebral pulsatility compared with men, particularly during midlife.
Cross-Sectional
Do age-associated increases in middle cerebral artery pulsatility and large artery stiffness differ between men and women?
Women exhibit accelerated age-associated increases in cerebral pulsatility during midlife compared to men, driven by exaggerated increases in carotid stiffness and pulse pressure, suggesting a potential mechanism for sex differences in brain aging.
We identify sex-specific associations between increasing age and cerebral pulsatility and its vascular mechanisms. When compared with men, women in our cross-sectional analysis exhibited greater age-associated increases in carotid stiffness, carotid pulse pressure, and cerebral pulsatility particularly during midlife. These data suggest that the rapid expansion of pulse pressure during midlife contributes to an exaggerated increase in cerebral pulsatility among women and suggest a potential mechanism contributing to sex differences in brain aging.
Lefferts et al. (Fri,) conducted a cross-sectional in Cerebral pulsatility. Female sex vs. Male sex was evaluated on Age-associated increases in carotid stiffness, carotid pulse pressure, and cerebral pulsatility. Women exhibited greater age-associated increases in carotid stiffness, carotid pulse pressure, and cerebral pulsatility compared with men, particularly during midlife.