Key result
Women show greater age-related increases in carotid stiffness and cerebral pulsatility than men during midlife.
Why the study?
The study sought to identify sex-specific associations between increasing age and cerebral pulsatility and its underlying vascular mechanisms.
Do age-associated increases in middle cerebral artery pulsatility and large artery stiffness differ between men and women?
Population
Men and women
Comparison
Women vs men across increasing age
Design
Cross-sectional analysis
Authors
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May support sex-specific midlife vascular monitoring; leaves open causal mechanisms and intervention effects.
Cross-Sectional
Do age-associated increases in middle cerebral artery pulsatility and large artery stiffness differ between men and women?
Women exhibit accelerated age-associated increases in cerebral pulsatility during midlife compared to men, driven by exaggerated increases in carotid stiffness and pulse pressure, suggesting a potential mechanism for sex differences in brain aging.
Lefferts et al. (2023) conducted a cross-sectional in Cerebral pulsatility. Female sex vs. Male sex was evaluated on Age-associated increases in carotid stiffness, carotid pulse pressure, and cerebral pulsatility. Women exhibited greater age-associated increases in carotid stiffness, carotid pulse pressure, and cerebral pulsatility compared with men, particularly during midlife.
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