Key result
The rate of middle cerebral artery blood velocity decline and flow pulsatility index rise across the adult lifespan is significantly greater in females compared with males.
Why the study?
The study was conducted to examine how age and sex affect middle cerebral artery blood velocity and flow pulsatility index across the adult lifespan.
How do age and sex affect middle cerebral artery blood velocity and flow pulsatility index across the adult lifespan?
Observational (n=524)
Yes
How do age and sex affect middle cerebral artery blood velocity and flow pulsatility index across the adult lifespan?
Females experience a significantly greater rate of middle cerebral artery blood velocity decline and flow pulsatility index rise with aging compared to males.
May suggest accelerated cerebrovascular aging in females; hypothesis-generating and requires longitudinal validation before clinical use.
= 524) pooled from three institutions to study how age and sex affect middle cerebral artery blood velocity (MCAv) and flow pulsatility index (PI) across the adult lifespan. We report the rate of MCAv decline and flow PI rise is significantly greater in females compared with in males. These data suggest that sex-specific trajectories with aging and therapeutic interventions to promote healthy brain aging should consider these findings.
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Alwatban et al. (2021) reported an observational. Female sex and aging vs. Male sex was evaluated on Middle cerebral artery blood velocity (MCAv) and flow pulsatility index (PI). The rate of middle cerebral artery blood velocity decline and flow pulsatility index rise across the adult lifespan is significantly greater in females compared with males.
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