Factor V Leiden mutation and protein C deficiency were significantly more prevalent in patients with venous thromboembolism compared to controls (P=0.003 and P=0.02, respectively).
Case-Control (n=382)
What is the prevalence of hereditary thrombophilic risk factors in patients with VTE, and do they differ by clinical manifestation (isolated PE, DVT, or PE+DVT)?
Factor V Leiden mutation and protein C deficiency are significant hereditary risk factors for VTE in this Turkish population, with combined defects predisposing to concurrent DVT and PE.
p-value: p=0.003 and 0.02
The aim of this study was to investigate the hereditary thrombophilic risk factors in patients with venous thromboembolism (VTE) and whether these risk factors play a different role in patients with isolated pulmonary embolism (PE) as compared with patients with deep vein thrombosis (DVT) and patients with PE + DVT. The protein C (PC), protein S, antithrombin activities, homocysteine levels, and factor V Leiden (FVL) G1691A and prothrombin G20210A mutations were evaluated in 191 patients with VTE and 191 controls. The prevalence of FVL and PC deficiency were higher in patients (P = .003 and P = .02, respectively). There was no significant difference for the other risk factors. The combination of thrombophilic risk factors was significantly higher in patients with DVT + PE as compared with patients with isolated PE or DVT (P = .04). In conclusion, the most important hereditary risk factors for VTE in this study were the FVL mutation and PC deficiency.
Okumuş et al. (Tue,) conducted a case-control in Venous thromboembolism (n=382). Hereditary thrombophilic risk factors vs. Controls without venous thromboembolism was evaluated on Prevalence of hereditary thrombophilic risk factors (p=0.003 and 0.02). Factor V Leiden mutation and protein C deficiency were significantly more prevalent in patients with venous thromboembolism compared to controls (P=0.003 and P=0.02, respectively).