Key result
Factor V Leiden mutation and protein C deficiency were significantly more prevalent in patients with venous thromboembolism compared to controls (P=0.003 and P=0.02, respectively).
Why the study?
What is the prevalence of hereditary thrombophilic risk factors in patients with VTE, and do they differ by clinical manifestation (isolated PE, DVT, or PE+DVT)?
Case-Control (n=382)
What is the prevalence of hereditary thrombophilic risk factors in patients with VTE, and do they differ by clinical manifestation (isolated PE, DVT, or PE+DVT)?
Factor V Leiden mutation and protein C deficiency are significant hereditary risk factors for VTE in this Turkish population, with combined defects predisposing to concurrent DVT and PE.
The aim of this study was to investigate the hereditary thrombophilic risk factors in patients with venous thromboembolism (VTE) and whether these risk factors play a different role in patients with isolated pulmonary embolism (PE) as compared with patients with deep vein thrombosis (DVT) and patients with PE + DVT. The protein C (PC), protein S, antithrombin activities, homocysteine levels, and factor V Leiden (FVL) G1691A and prothrombin G20210A mutations were evaluated in 191 patients with VTE and 191 controls. The prevalence of FVL and PC deficiency were higher in patients (P = .003 and P = .02, respectively). There was no significant difference for the other risk factors. The combination of thrombophilic risk factors was significantly higher in patients with DVT + PE as compared with patients with isolated PE or DVT (P = .04). In conclusion, the most important hereditary risk factors for VTE in this study were the FVL mutation and PC deficiency.
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Okumuş et al. (2007) conducted a case-control in Venous thromboembolism (n=382). Hereditary thrombophilic risk factors vs. Controls without venous thromboembolism was evaluated on Prevalence of hereditary thrombophilic risk factors (p=0.003 and 0.02). Factor V Leiden mutation and protein C deficiency were significantly more prevalent in patients with venous thromboembolism compared to controls (P=0.003 and P=0.02, respectively).
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