Low-Dose Dobutamine Tissue-Tagged Magnetic Resonance Imaging With 3-Dimensional Strain Analysis Allows Assessment of Myocardial Viability in Patients With Ischemic Cardiomyopathy

BACKGROUND: Tissue-tagged magnetic resonance imaging (MRI) with 3-dimensional (3D) myocardial strain analysis allows quantitative assessment of myocardial contractility. We assessed the hypothesis that 3D strain determination at rest and with low-dose dobutamine would discriminate between viable and nonviable myocardium in patients with ischemic cardiomyopathy (ICM). METHODS AND RESULTS: MRI with radiofrequency tissue-tagging at rest and with low-dose dobutamine was performed in 16 normal volunteers and 14 patients with ICM. Three-dimensional global and regional circumferential strains (Ecc) were computed for all subjects at rest and with dobutamine. Results were compared with clinically indicated conventional viability studies. Compared with normal volunteers, global left ventricular Ecc was significantly decreased in patients with ICM at rest (-0.15+/-0.06 versus -0.27+/-0.03; P<0.001) and with dobutamine (-0.17+/-0.08 versus -0.37+/-0.10; P<0.001). Ecc was significantly decreased in nonviable regions compared with viable segments at rest (-0.08+/-0.06 versus -0.17+/-0.10; P<0.001) and with dobutamine (-0.07+/-0.06 versus -0.21+/-0.11; P<0.001). Ecc in viable segments increased significantly in response to dobutamine (P=0.04), whereas Ecc did not change in nonviable segments (P=0.50). Normal controls (96 segments) had increased Ecc at rest (-0.27+/-0.07) and with dobutamine (-0.37+/-0.15) compared with both viable and nonviable regions in ICM patients (P<0.001). CONCLUSIONS: Noninvasive dobutamine tissue-tagged MRI with calculation of 3D strain allows the identification, quantification and display of regionally varying ventricular function. The response of systolic strain to low-dose dobutamine has significant promise in discriminating between viable and nonviable myocardium.