Key result
Low-dose dobutamine tissue-tagged MRI with 3D strain analysis discriminated viable from nonviable myocardium; strain increased in viable segments (P=0.04) but not in nonviable segments (P=0.50).
Why the study?
Does tissue-tagged MRI with 3D strain analysis at rest and with low-dose dobutamine discriminate between viable and nonviable myocardium in patients with ischemic cardiomyopathy?
Observational (n=30)
Does tissue-tagged MRI with 3D strain analysis at rest and with low-dose dobutamine discriminate between viable and nonviable myocardium in patients with ischemic cardiomyopathy?
p-value: p=<0.001
Low-dose dobutamine tissue-tagged MRI with 3D strain analysis can effectively discriminate between viable and nonviable myocardium in patients with ischemic cardiomyopathy.
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May support viability assessment in ischemic cardiomyopathy; hypothesis-generating and requires prospective validation before practice change.
Bree et al. (2006) conducted an observational in Ischemic cardiomyopathy (n=30). Tissue-tagged MRI with 3D strain analysis vs. Rest / Normal volunteers was evaluated on 3-dimensional global and regional circumferential strains (Ecc) at rest and with dobutamine (p=<0.001). Low-dose dobutamine tissue-tagged MRI with 3D strain analysis discriminated viable from nonviable myocardium; strain increased in viable segments (P=0.04) but not in nonviable segments (P=0.50).
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