What question did this study set out to answer?

The study aims to assess left ventricular function using MRI during dobutamine-induced stress in normal human subjects.

April 2, 1993European Heart Journal

Quantitation of global and regional left ventricular function by cine magnetic resonance imaging during dobutamine stress in normal human subjects

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Why the study?

Does dobutamine stress during cine MRI allow for the quantitation of global and regional left ventricular function in normal human subjects?

Population

23 normal human subjects

Comparison

Dobutamine infusion during cine magnetic… vs Rest (control state)

Design

Cross-sectional

Authors

FRF. Paul van RuggeLeiden University EHEduard R. HolmanCardiac Imaging EWE. E. van der WallCardiac Imaging

Discussion

Member takes

Implication

Supports dobutamine cine MRI for LV quantitation in normals; leaves open validation in patients before clinical use.

Key Points

The study aims to assess left ventricular function using MRI during dobutamine-induced stress in normal human subjects.
Conducted an MRI evaluation during dobutamine infusion (15 micrograms.kg-1 x min-1) in 23 normal human subjects.
Measured haemodynamics, ventricular volumes, and wall thickening at rest and peak infusion using short-axis views of the left ventricle.
Analyzed segmental wall motion and thickening across 18 segments of the left ventricle.
Heart rate, systolic and diastolic blood pressures, stroke index, cardiac output, and left ventricular ejection fraction all significantly increased during dobutamine (P < 0.001).
Systolic wall thickening increased significantly (P < 0.001) in all segments during dobutamine, except for apical and low-left ventricular levels.
Segmental wall motion analysis showed the highest wall thickening at the posterolateral area and the lowest at the septal region (P < 0.05).

Structured PICO

Does dobutamine stress during cine MRI allow for the quantitation of global and regional left ventricular function in normal human subjects?

Population

23 normal human subjects

Intervention

Dobutamine infusion (15 micrograms.kg-1 x min-1) during cine magnetic resonance imaging (MRI)

Comparator

Rest (control state)

Outcome

Haemodynamics, ventricular volumes, and percent systolic wall thickening (%WTh)surrogate

Cine MRI during dobutamine stress is a feasible method to quantify global and regional left ventricular function and hemodynamics without the motion artifacts associated with physical exercise.

Cite This Study

Rugge et al. (1993) studied this question.

synapsesocial.com/papers/6a15625679ff98d0de4e8cd4 https://doi.org/10.1093/eurheartj/14.4.456

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Quantitation of global and regional left ventricular function by cine magnetic resonance imaging during dobutamine stress in normal human subjects

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Quantitation of global and regional left ventricular function by cine magnetic resonance imaging during dobutamine stress in normal human subjects

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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