What does this research mean for the field?

Combining preserved end-diastolic wall thickness and dobutamine-inducible contraction reserve assessed by MRI maximizes sensitivity for detecting viable myocardium in patients with chronic coronary artery disease, closely matching FDG-PET results. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 15, 1995Circulation

Comparison of Low-Dose Dobutamine–Gradient-Echo Magnetic Resonance Imaging and Positron Emission Tomography With 18 FFluorodeoxyglucose in Patients With Chronic Coronary Artery Disease

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Why the study?

Does low-dose dobutamine MRI accurately detect myocardial viability compared to FDG-PET in patients with previous myocardial infarction and regional akinesia?

Population

35 patients with myocardial infarction and regional akinesia or dyskinesia assessed by left ventriculography

Comparison

Low-dose dobutamine gradient-echo magnetic… vs Positron emission tomography with…

Design

Cross-sectional

Authors

FBFrank M. BaerGoethe University Frankfurt EVEberhard VothKlinik und Poliklinik für Nuklearmedizin CSChristian SchneiderRadboud University Nijmegen

Discussion

Member takes

Implication

Dobutamine MRI may support viability assessment in post-MI akinesia; extends conflicting wall-thickness data but leaves open outcome impact versus PET.

Structured PICO

Does low-dose dobutamine MRI accurately detect myocardial viability compared to FDG-PET in patients with previous myocardial infarction and regional akinesia?

Population

35 patients with myocardial infarction (infarct age > 4 months) and regional akinesia or dyskinesia assessed by left ventriculography

Intervention

Low-dose dobutamine (10 micrograms/kg/min) gradient-echo magnetic resonance imaging (MRI) assessing end-diastolic wall thickness and systolic wall thickening

Comparator

Positron emission tomography with [18F]fluorodeoxyglucose (FDG-PET)

Outcome

Diagnostic agreement and correlation between MRI parameters (end-diastolic wall thickness and dobutamine-induced contraction reserve) and FDG-PET for myocardial viabilitysurrogate

Combining end-diastolic wall thickness and dobutamine-induced contraction reserve on MRI maximizes sensitivity for detecting myocardial viability compared to the FDG-PET reference standard.

Cite This Study

Baer et al. (1995) studied this question.

synapsesocial.com/papers/6a1d643732d43530c25da7c8 https://doi.org/10.1161/01.cir.91.4.1006

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Implication

Dobutamine MRI may support viability assessment in post-MI akinesia; extends conflicting wall-thickness data but leaves open outcome impact versus PET.