Higher total energy expenditure significantly predicted decreased CHD risk (P for trend=0.046), whereas the duration of individual exercise sessions had no independent effect (P for trend=0.25).
Cohort (n=7,307)
Does the duration of exercise episodes or total energy expenditure independently predict the risk of developing coronary heart disease in men?
Total energy expenditure, rather than the duration of individual exercise sessions, is the primary determinant of physical activity-associated reduction in coronary heart disease risk.
p-value: p=0.046
BACKGROUND: Physical activity is associated with a decreased risk of coronary heart disease (CHD). However, it is unclear whether the duration of exercise episodes is important: Are accumulated shorter sessions as predictive of decreased risk as longer sessions if the same amount of energy is expended? METHODS AND RESULTS: In the Harvard Alumni Health Study, we prospectively followed 7307 Harvard University alumni (mean age 66.1 years) from 1988 through 1993. At baseline, men reported their walking, stair climbing, and participation in sports or recreational activities. For each of the latter activities, they also reported the frequency and average duration per episode. During follow-up, 482 men developed CHD. In age-adjusted analysis, a longer duration of exercise episodes predicted lower CHD risk (P: trend=0.04). However, after total energy expended on physical activity and potential confounders was accounted for, duration no longer had an independent effect on CHD risk (P: trend=0.25); that is, longer sessions of exercise did not have a different effect on risk compared with shorter sessions, as long as the total energy expended was similar. In contrast, higher levels of total energy expenditure significantly predicted decreased CHD risk in both age-adjusted (P: trend=0.009) and multivariate (P: trend=0.046) analyses. CONCLUSIONS: These data clearly indicate that physical activity is associated with decreased CHD risk. Furthermore, they lend some support to recent recommendations that allow for the accumulation of shorter sessions of physical activity, as opposed to requiring 1 longer, continuous session of exercise. This may provide some impetus for those sedentary to become more active.
Lee et al. (Tue,) conducted a cohort in Coronary heart disease (n=7,307). Physical activity was evaluated on Coronary heart disease (p=0.046). Higher total energy expenditure significantly predicted decreased CHD risk (P for trend=0.046), whereas the duration of individual exercise sessions had no independent effect (P for trend=0.25).