August 29, 2000Circulation
Physical Activity and Coronary Heart Disease Risk in Men
Key result
Higher total energy expenditure significantly predicted decreased CHD risk (P for trend=0.046), whereas the duration of individual exercise sessions had no independent effect (P for trend=0.25).
Why the study?
Does the duration of exercise episodes or total energy expenditure independently predict the risk of developing coronary heart disease in men?
Population
7,307 male Harvard University alumni, mean age 66.1 years.
Comparison
Higher levels of total energy expenditure from… vs Lower levels of total energy expenditure and…
Design
Cohort
Follow-up
From 1988 through 1993
Authors
Discussion
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Member takes
Implication
Total energy expenditure may matter more than bout duration for CHD risk reduction; supports flexible activity guidelines but leaves open need for trial confirmation.
Key Points
- To examine whether physical activity episode duration independently predicts coronary heart disease risk or if accumulated shorter exercise sessions provide similar risk reduction when total energy expenditure is equivalent.
- Prospective cohort follow-up of 7,307 Harvard University alumni (mean age 66.1 years) from 1988 through 1993 in the Harvard Alumni Health Study.
- Self-reported baseline walking, stair climbing, and sports/recreational activities, including frequency and average duration per episode.
- During follow-up, 482 men developed coronary heart disease.
- Longer exercise episode duration predicted lower CHD risk in age-adjusted analysis (P trend = 0.04), but this effect was not significant after adjusting for total energy expenditure and confounders (P trend = 0.25).
- Higher total energy expenditure significantly predicted reduced CHD risk in both age-adjusted (P trend = 0.009) and multivariate-adjusted (P trend = 0.046) analyses.
Study Design
Type
Cohort (n=7,307)
Structured PICO
Does the duration of exercise episodes or total energy expenditure independently predict the risk of developing coronary heart disease in men?
P
Population
7,307 male Harvard University alumni, mean age 66.1 years.
I
Intervention
Higher levels of total energy expenditure from physical activity (including walking, stair climbing, and sports or recreational activities) and varying durations of exercise episodes.
C
Comparator
Lower levels of total energy expenditure and different durations of exercise episodes.
O
Outcome
Development of coronary heart disease (CHD) during follow-up from 1988 through 1993.hard clinical
Main Result
p-value: p=0.046
Total energy expenditure, rather than the duration of individual exercise sessions, is the primary determinant of physical activity-associated reduction in coronary heart disease risk.
Cite This Study
Lee et al. (2000) conducted a cohort in Coronary heart disease (n=7,307). Physical activity was evaluated on Coronary heart disease (p=0.046). Higher total energy expenditure significantly predicted decreased CHD risk (P for trend=0.046), whereas the duration of individual exercise sessions had no independent effect (P for trend=0.25).