December 1, 1995American Journal of Epidemiology
Physical Exercise and Reduced Risk of Nonfatal Myocardial Infarction
Key result
Highest physical activity quartile linked to ~50% lower MI risk in men but not women.
- RR 0.50
- 95% CI 0.31-0.80
- n=680
Why the study?
Does higher physical activity reduce the risk of first nonfatal myocardial infarction?
Population
680 adults from the Boston Area Health Study, comprising 340 patients who survived a first myocardial…
Comparison
Highest quartile of physical activity or highest… vs Lowest quartile of physical activity or least…
Design
Case-control
Authors
Discussion
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Member takes
Implication
Should not yet alter activity guidance by sex; leaves open causality and sex differences pending prospective data.
Study Design
Type
Case-Control (n=680)
Structured PICO
Does higher physical activity reduce the risk of first nonfatal myocardial infarction?
P
Population
680 participants comprising 340 survivors of a first myocardial infarction and 340 matched controls from the Boston area.
E
Exposure
Highest quartile of physical activity or highest level of energy expenditure on moderate to vigorous sports
C
Comparator
Lowest quartile of physical activity or least active category
O
Outcome
Risk of first nonfatal myocardial infarctionhard clinical
Main Result
Relative Risk: 0.5 (95% CI 0.31–0.8)
Physical activity is inversely related to the risk of nonfatal myocardial infarction, independent of other coronary heart disease risk factors.
Cite This Study
Hennekens et al. (1995) conducted a case-control in Myocardial infarction (n=680). Highest quartile of physical activity vs. Lowest quartile of physical activity was evaluated on Myocardial infarction (RR 0.50, 95% CI 0.31-0.80). The highest quartile of physical activity was associated with a reduced relative risk of myocardial infarction in men (RR 0.50; 95% CI 0.31-0.80), but not in women (RR 1.00; 95% CI 0.41-2.43).