Why the study?
Does vigorous physical activity reduce the risk of myocardial infarction in men, and is this mediated by cardiovascular biomarkers?
Population
18,225 men in the Health Professionals Follow-up Study, from which a nested case-control study was conducted…
Comparison
3-h·wk increase in vigorous-intensity activity vs Lower levels of vigorous-intensity activity
Design
Case-control
Follow-up
1994 to 2004
Authors
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Vigorous activity was associated with lower MI risk in men; leaves open causality and biomarker mediation.
Does vigorous physical activity reduce the risk of myocardial infarction in men, and is this mediated by cardiovascular biomarkers?
Participating in 3 hours per week of vigorous-intensity activity is associated with a 22% lower risk of MI among men, which is partially mediated by beneficial effects on HDL-C, vitamin D, apolipoprotein B, and hemoglobin A1c.
Chomistek et al. (2011) studied this question.
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