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December 28, 2018Bangladesh Heart JournalOpen Access

Correlation between Inflammatory Marker and Glycemic Control in Patients with Ischemic Heart Disease

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Why the study?

Inflammatory markers and poor glycemic control are associated with cardiovascular complications, prompting evaluation of the association between CRP and HbA1c in ischemic heart disease patients.

Is there a correlation between glycemic control (HbA1c) and systemic inflammation (CRP) in patients with ischemic heart disease?

Population

668 patients with ischemic heart disease undergoing coronary angiography

Comparison

CRP categories and HbA1c levels (<6.5% vs ≥6.5%)

Design

Cross-sectional study

Key result

HbA1c levels were significantly and positively correlated with CRP levels (r=0.220, p=0.001) in patients with ischemic heart disease.

Authors

MAMohsin AhmedMIMd Mesbahul IslamMRMohammad Arifur Rahman

Discussion

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Member takes

Overview

Association between HbA1c and CRP in IHD is hypothesis-generating; leaves open causality and should not yet change practice.

Study Design

Type

Cross-Sectional (n=668)

Multicenter

No

Structured PICO

Is there a correlation between glycemic control (HbA1c) and systemic inflammation (CRP) in patients with ischemic heart disease?

P
Population
668 patients with ischemic heart disease (chronic stable angina, unstable angina, NSTEMI, and STEMI) who underwent coronary angiography, mean age 51.4 years, 82.3% male, based in Bangladesh.
O
Outcome
Correlation between inflammatory marker (CRP) and glycemic status (HbA1c), and their association with the extent of coronary artery disease severity (single, double, or triple vessel CAD).surrogate

Main Result

Effect estimate: r=0.220

p-value: p=0.001

Limitations

  • Cross-sectional design cannot infer causality between poor glycemic control and inflammation
  • Cross-sectional design cannot establish causality between poor glycemic control and inflammation
  • Single-center study

Cite This Study

Ahmed et al. (2018) conducted a cross-sectional in Ischemic heart disease (n=668). HbA1c and CRP assessment was evaluated on Correlation between HbA1c and CRP (r=0.220, p=0.001). HbA1c levels were significantly and positively correlated with CRP levels (r=0.220, p=0.001) in patients with ischemic heart disease.

synapsesocial.com/papers/6a15f9e84718e7db3a524572https://doi.org/10.3329/bhj.v33i2.39305
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