Preventing the blood pressure increase after sinoaortic denervation with sodium nitroprusside significantly increased plasma renin activity (5.86 vs 1.67 ng AngI/mL/h; P<0.05).
Preventing the rise in blood pressure after sinoaortic denervation in rats unmasks an increase in plasma renin activity, indicating that elevated blood pressure offsets sympathetically mediated renin release.
Absolute Event Rate: 5.86% vs 1.67%
p-value: p=<0.05
Blood pressure (BP) and heart rate (HR) increase 6 and 24 h after sinoaortic baroreceptor denervation (SAD), whereas plasma renin activity (PRA) and renal renin mRNA levels remain unchanged. We postulated that a simultaneous rise in BP could offset the expected activation of renin associated with an increased renal sympathetic discharge secondary to SAD. 2. To test this hypothesis, the increase in BP associated with the onset of SAD was prevented by a continuous infusion of sodium nitroprusside (SNP; 30 microg/kg per h). Changes were measured in five groups of conscious adult male Wistar rats: (i) sham; (ii) SAD; (iii) SAD rats in which the BP was prevented from increasing by infusion of SNP; (iv) sham rats in which the BP was increased by 30% by infusion of phenylephrine (PE; 1.5-2.0 mL/h); and (v) SNP + PE for 3 h by infusion as above. 3. As expected, BP and heart rate (HR) increased significantly following SAD compared with sham rats (152 +/- 4 vs 116 +/- 3 mmHg, respectively, for BP and 503 +/- 6 vs 345 +/- 13 b.p.m., respectively for HR; n = 5; P < 0.05) but remained unchanged when SNP was infused for 3 h (106 +/- 1 mmHg and 455 +/- 9 b.p.m., respectively; n = 5; P < 0.05). 4. Similarly, BP and HR increased with PE infusion compared with PE + SNP (138 +/- 9.9 vs 113 +/- 2.3 mmHg for BP, respectively, and 325 +/- 9 vs 423 +/- 18 b.p.m. for HR, respectively; n = 5; P < 0.05). 5. Plasma renin activity remained unchanged in SAD compared with sham rats (1.67 +/- 0.35 vs 1.05 +/- 0.17 ng angiotensin (Ang) I/mL per h), but increased significantly when hypertension was prevented (5.86 +/- 0.77 ng AngI/mL per h; n = 5; P < 0.05). Renin mRNA levels in the kidneys were unchanged in all groups. 6. These results show that an elevation in BP appears to offset increased renal sympathetic discharge with no change in PRA.
Krieger et al. (Mon,) conducted a other in Sinoaortic baroreceptor denervation (n=25). Sodium nitroprusside (SNP) infusion vs. Sham, SAD alone, Sham + PE, SNP + PE was evaluated on Plasma renin activity (PRA) (p=<0.05). Preventing the blood pressure increase after sinoaortic denervation with sodium nitroprusside significantly increased plasma renin activity (5.86 vs 1.67 ng AngI/mL/h; P<0.05).