Key result
Preventing the blood pressure increase after sinoaortic denervation with sodium nitroprusside significantly increased plasma renin activity (5.86 vs 1.67 ng AngI/mL/h; P<0.05).
Population
Conscious adult male Wistar rats (5 groups, n=5 per group)
Comparison
Sinoaortic baroreceptor denervation with… vs Sham rats, SAD alone, or sham with PE/SNP
Design
Preclinical
Follow-up
3 hours
Authors
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Hypothesis-generating for baroreflex-renin interactions in hypertension; should not change clinical practice.
Absolute Event Rate: 5.86% vs 1.67%
p-value: p=<0.05
Preventing the rise in blood pressure after sinoaortic denervation in rats unmasks an increase in plasma renin activity, indicating that elevated blood pressure offsets sympathetically mediated renin release.
Krieger et al. (2006) studied Sinoaortic baroreceptor denervation (n=25). Sodium nitroprusside (SNP) infusion vs. Sham, SAD alone, Sham + PE, SNP + PE was evaluated on Plasma renin activity (PRA) (p=<0.05). Preventing the blood pressure increase after sinoaortic denervation with sodium nitroprusside significantly increased plasma renin activity (5.86 vs 1.67 ng AngI/mL/h; P<0.05).
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