Population
Rats (n=44 denervated rats) used as a model of arterial baroreflex deficit
Comparison
Sinoaortic denervation, isolated… vs Sham operation
Design
Preclinical
Follow-up
18 weeks
Authors
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Hypothesis-generating in animal models; leaves open whether baroreflex enhancement reduces human end-organ damage.
Arterial baroreflex deficit plays an independent and important role in target-organ damage, driven by significantly elevated 24-hour blood pressure variability.
Shan et al. (2001) studied this question.
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