Why the study?
Does sino-aortic denervation cause respiratory changes associated with normal mean arterial pressure in rats?
Population
Male juvenile Wistar rats (postnatal day 19–21), n=52
Comparison
Sino-aortic denervation or selective removal of… vs Sham surgery
Design
Preclinical
Follow-up
10 days after surgery
Authors
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SAD alters breathing patterns without raising mean pressure in rats; leaves open whether respiratory mechanisms drive variability in human baroreflex failure.
Does sino-aortic denervation cause respiratory changes associated with normal mean arterial pressure in rats?
Sino-aortic denervation in rats induces respiratory changes, such as reduced respiratory frequency, which may act as a compensatory mechanism to maintain normal mean arterial pressure levels.
Amorim et al. (2016) studied this question.
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