Key result
Sinoaortic denervation in conscious rats significantly reduced basal plasma ANP levels and the ANP response to a hypertonic saline challenge (peak 30.8 vs 136.8 in sham; P<0.01).
Why the study?
Does sinoaortic denervation reduce basal plasma ANP levels and the response to an osmotic challenge in conscious rats?
Population
Conscious rats
Comparison
Sinoaortic denervation followed by iv hypertonic… vs Sham-operated rats followed by iv hypertonic…
Design
Preclinical
Follow-up
5 min
Authors
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Rat data suggest baroreceptor control of ANP; leaves open relevance to human cardiovascular disease.
Does sinoaortic denervation reduce basal plasma ANP levels and the response to an osmotic challenge in conscious rats?
Absolute Event Rate: 30.8% vs 136.8%
p-value: p=<0.01
Sinoaortic denervation significantly reduces basal plasma ANP levels and blunts the ANP response to an osmotic challenge in conscious rats, suggesting baroreceptor influence on hormonal regulation.
Morris et al. (1988) studied this question. Sinoaortic denervation (SAD) vs. Sham operation was evaluated on Plasma ANP response to iv hypertonic saline challenge (p=<0.01). Sinoaortic denervation in conscious rats significantly reduced basal plasma ANP levels and the ANP response to a hypertonic saline challenge (peak 30.8 vs 136.8 in sham; P<0.01).
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