Key result
Volume expansion by acute intravenous saline infusion significantly increased plasma ANP levels compared to control rats (453 vs 170 pg/ml, p<0.01), independent of the cardiopulmonary baroreflex.
Population
Pentobarbital-anesthetized male Wistar rats
Comparison
Volume expansion and volume depletion, with or… vs Control rats or baseline state
Design
Preclinical
Authors
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ANP release during volume expansion is baroreflex-independent in rats; leaves open translation to human physiology and clinical relevance.
Absolute Event Rate: 453% vs 170%
p-value: p=<0.01
Plasma ANP responds to both volume expansion and moderate volume depletion independently of the cardiopulmonary baroreflex with vagal afferent in rats.
Yoshida et al. (1987) studied Pentobarbital-anesthetized male Wistar rats. Volume expansion (acute intravenous saline infusion) vs. Control rats was evaluated on Plasma ANP levels (p=<0.01). Volume expansion by acute intravenous saline infusion significantly increased plasma ANP levels compared to control rats (453 vs 170 pg/ml, p<0.01), independent of the cardiopulmonary baroreflex.
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