Complementary Changes in Plasma Atrial Natriuretic Peptide and Antidiuretic Hormone Concentrations in Response to Volume Expansion and Haemorrhage: Studies in Conscious Normotensive and Spontaneously Hypertensive Rats
Population
Conscious stroke-prone spontaneously hypertensive, spontaneously hypertensive and normotensive Wistar-Kyoto…
Comparison
Acute volume expansion or haemorrhage vs Resting values and comparison between…
Design
Preclinical
Follow-up
Up to 30 minutes
Authors
Discussion
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Implication
Animal data confirm reciprocal ANP-ADH volume responses in rats; leaves open translation to human hypertension.
Structured PICO
P
Population
Conscious stroke-prone spontaneously hypertensive (SPR), spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats
I
Intervention
Acute volume expansion (infusion of 2.0 ml per 100 g 5% dextrose) or haemorrhage (1.5 ml of blood per 100 g bodyweight)
C
Comparator
Resting values (baseline) and comparison between hypertensive and normotensive strains
O
Outcome
Plasma concentrations of atrial natriuretic peptide (ANP) and antidiuretic hormone (ADH)surrogate
Plasma ANP and ADH exhibit complementary, reciprocal changes in response to acute volume expansion and hemorrhage in both normotensive and hypertensive rats.
Cite This Study
Morris et al. (1987) studied this question.