Why the study?
Does atrial natriuretic peptide affect blood pressure and urinary excretion differently in spontaneously hypertensive and normotensive rats on a high sodium diet?
Population
Spontaneously hypertensive rats and Wistar-Kyoto rats maintained on tap water or 1.5% NaCl for 3 weeks
Comparison
Atrial natriuretic peptide administered as bolus… vs Responses compared between rat strains and diets
Design
Preclinical
Follow-up
Acute monitoring at 5-min intervals after 3 weeks of diet
Authors
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High-sodium diets may blunt ANP natriuresis more in hypertensive models; hypothesis-generating for salt-sensitive hypertension mechanisms.
Does atrial natriuretic peptide affect blood pressure and urinary excretion differently in spontaneously hypertensive and normotensive rats on a high sodium diet?
A high sodium diet down-regulates target organ responsiveness to ANP, with an inappropriately large decrease in responsiveness observed in spontaneously hypertensive rats.
Gradin et al. (1987) studied this question.
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