Why the study?
Does chronic infusion of atrial natriuretic factor alter blood pressure and ANF receptors in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY)
Comparison
Atrial natriuretic factor 100 ng/h for 7 days by… vs Non-infused spontaneously hypertensive rats and…
Design
Preclinical
Follow-up
7 days
Authors
Loading...
Caution against clinical translation from SHR models; leaves open whether preserved vascular ANF receptors mediate sustained BP effects.
Does chronic infusion of atrial natriuretic factor alter blood pressure and ANF receptors in spontaneously hypertensive rats?
Chronic ANF infusion lowers blood pressure in spontaneously hypertensive rats, which may be associated with the lack of change in vascular ANF receptors.
Cachofeiro et al. (1989) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: