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November 1, 1986AJP Renal Physiology

Effect of atrial natriuretic factor on renal hemodynamics in the rat

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Key result

Infusions of synthetic ANF produced dose-related increases in sodium and water excretion without requiring an increase in renal blood flow or glomerular filtration rate.

Why the study?

Does synthetic atrial natriuretic factor alter renal hemodynamics and excretory function in anesthetized rats?

Population

Anesthetized, euvolemic Munich-Wistar rats

Comparison

Synthetic atrial natriuretic factor infused… vs Different routes of administration and baseline…

Design

Preclinical

Authors

DPDavid M. PollockPreventive CardiologyWAWilliam J. ArendshorstUniversity of North Carolina at Chapel Hill

Discussion

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Implication

Should not change clinical diuretic use; hypothesis-generating for ANF mechanisms in human cardiorenal research.

Structured PICO

Does synthetic atrial natriuretic factor alter renal hemodynamics and excretory function in anesthetized rats?

P
Population
Anesthetized, euvolemic Munich-Wistar rats.
I
Intervention
Synthetic atrial natriuretic factor (ANF, 28 amino acids) infused intra-aortically or intravenously at doses of 7.5, 15, and 30 micrograms/kg/h
C
Comparator
Different routes of administration (intra-aortic vs. intravenous) and baseline states
O
Outcome
Renal hemodynamics and excretory function (absolute and fractional sodium and water excretion, renal blood flow, mean arterial pressure, glomerular filtration rate)surrogate

Synthetic ANF induces diuresis and natriuresis in rats without requiring an increase in renal blood flow or glomerular filtration rate.

Cite This Study

Pollock et al. (1986) studied Anesthetized, euvolemic Munich-Wistar rats. Synthetic atrial natriuretic factor (ANF) was evaluated on Renal hemodynamics and excretory function (sodium and water excretion, RBF, GFR). Infusions of synthetic ANF produced dose-related increases in sodium and water excretion without requiring an increase in renal blood flow or glomerular filtration rate.

synapsesocial.com/papers/6a9cd22448effd99aa57b61ahttps://doi.org/10.1152/ajprenal.1986.251.5.f795
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of synthetic atrial natriuretic factor on renal function and renin release1984 · 535 citations
  2. 2Relationship between renal hemodynamic and natriuretic effects of atrial natriuretic factor1986 · 107 citations
  3. 3Effects of synthetic atrial natriuretic factor in the isolated perfused rat kidney1985 · 33 citations
  4. 4Renal sites of action of physiological increases in plasma atrial natriuretic factor concentration in essential hypertension1992 · 36 citations
  5. 5Natriuretic and diuretic effects of infusion of atrial natriuretic factor in conscious dogs1989 · 4 citations