Key result
Chronic infusion of synthetic ANF (8-33) in hypertensive rats decreased blood pressure from 183 +/- 4 mmHg to 116 +/- 5 mmHg and significantly lowered plasma renin activity.
Why the study?
Does chronic infusion of synthetic ANF (8-33) reduce blood pressure in two-kidney, one-clip hypertensive rats?
Population
Conscious two-kidney, one-clip hypertensive rats
Comparison
Chronic infusion of synthetic Atrial Natriuretic… vs Untreated hypertensive rats
Design
Preclinical
Follow-up
7 days
Authors
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ANF infusion may lower BP in renovascular hypertension models; leaves open translation to human therapy.
Does chronic infusion of synthetic ANF (8-33) reduce blood pressure in two-kidney, one-clip hypertensive rats?
Chronic infusion of synthetic ANF (8-33) effectively lowers blood pressure, reduces plasma renin activity, and partially reverses cardiac hypertrophy in a rat model of renovascular hypertension.
Garcı́a et al. (1985) studied Two-kidney, one-clip hypertension. Synthetic Atrial Natriuretic Factor (ANF 8-33) vs. Not treated hypertensive rats was evaluated on Blood pressure. Chronic infusion of synthetic ANF (8-33) in hypertensive rats decreased blood pressure from 183 +/- 4 mmHg to 116 +/- 5 mmHg and significantly lowered plasma renin activity.
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