What question did this study set out to answer?

This research aims to assess the hemodynamic effects of synthetic rat atrial natriuretic peptide (rANP) in hypertensive and normotensive rats.

May 1, 1989AJP Heart and Circulatory Physiology

Hemodynamic effects of chronic infusion of rANP in renal hypertensive rats

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Why the study?

Does chronic infusion of rANP reduce blood pressure and alter hemodynamics in conscious normotensive and two-kidney, one-clip hypertensive rats?

Population

Conscious normotensive and two-kidney, one-clip hypertensive (2K,1C) rats

Comparison

Synthetic rat atrial natriuretic peptide 0.5… vs Normotensive rats receiving the same dose, and…

Design

Preclinical

Follow-up

5 days

Authors

FFFrancisco J. FenoyUniversidad de Murcia TQT. QuesadaMayo Clinic MGMiguel Garcı́a-SalomUniversidad de Murcia

Discussion

Member takes

Implication

May warrant ANP analog trials in hypertension; hypothesis-generating from animal data and should not yet change practice.

Key Points

This research aims to assess the hemodynamic effects of synthetic rat atrial natriuretic peptide (rANP) in hypertensive and normotensive rats.
Infused rANP (0.5 micrograms/h iv) for 5 consecutive days in conscious normotensive and 2K,1C hypertensive rats.
Monitored mean arterial pressure (MAP), cardiac index (CI), plasma ANP levels, and plasma renin activity (PRA).
In hypertensive rats, MAP decreased from 169 +/- 3 to 138 +/- 3 mmHg after 5 days of infusion (p<0.001).
Cardiac index fell from 400 +/- 16 to 348 +/- 14 ml.min-1.kg-1 after 2 days before returning to baseline levels.
In normotensive rats, no change in MAP was observed, but CI decreased temporarily during initial infusion days.

Structured PICO

Does chronic infusion of rANP reduce blood pressure and alter hemodynamics in conscious normotensive and two-kidney, one-clip hypertensive rats?

Population

Conscious normotensive and two-kidney, one-clip hypertensive (2K,1C) rats

Intervention

Synthetic rat atrial natriuretic peptide (rANP) 0.5 micrograms/h iv infusion for 5 consecutive days

Comparator

Normotensive rats receiving the same dose, and baseline values

Outcome

Hemodynamic effects including mean arterial pressure (MAP), cardiac index (CI), and total peripheral resistance (TPR)surrogate

Chronic infusion of rANP lowers mean arterial pressure in renal hypertensive rats through a transitory decrease in cardiac index followed by a sustained decrease in total peripheral resistance.

Cite This Study

Fenoy et al. (1989) studied this question.

synapsesocial.com/papers/6a7108da31a3df82432942ed https://doi.org/10.1152/ajpheart.1989.256.5.h1393

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Hemodynamic effects of chronic infusion of rANP in renal hypertensive rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Hemodynamic effects of chronic infusion of rANP in renal hypertensive rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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