What does this research mean for the field?

Atrial natriuretic peptide infusion decreases mean arterial blood pressure by approximately 10% in both spontaneously hypertensive and normotensive rats, acting primarily via reduced cardiac output in normotensive animals and combined reductions in cardiac output and total peripheral resistance in hypertensive animals. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1988Acta Physiologica Scandinavica

Differential haemodynamic effects of atrial natriuretic peptide (ANP) in normotensive and spontaneously hypertensive rats

Q: What is the clinical evidence from this study?

Study design: Other. Population: Hypertension. Intervention: rat ANP (103-125) vs. Normotensive Wistar Kyoto (WKY) control rats. Primary outcome: Mean Arterial blood pressure (MAP).

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Key result

ANP infusion reduces MAP by ~10% in both hypertensive and normotensive rats.

Why the study?

The differential haemodynamic effects of atrial natriuretic peptide in normotensive versus spontaneously hypertensive rats were not fully characterized.

Does atrial natriuretic peptide infusion have differential effects on central haemodynamic parameters in spontaneously hypertensive versus normotensive rats?

Population

Conscious spontaneously hypertensive rats and normotensive Wistar Kyoto control rats

Comparison

ANP infusion effects in SHR versus WKY rats

Design

Preclinical experimental study

Follow-up

10 minutes

Authors

APA. PetterssonUppsala University SRSven‐Erik RickstenUniversity of Gothenburg JHJan HednerSahlgrenska University Hospital

Discussion

Member takes

Implication

Supports differential haemodynamic effects of ANP; leaves open applicability to human hypertension.

Structured PICO

Does atrial natriuretic peptide infusion have differential effects on central haemodynamic parameters in spontaneously hypertensive versus normotensive rats?

Population

Conscious spontaneously hypertensive rats and normotensive Wistar Kyoto control rats.

Intervention

10-min infusion of rat atrial natriuretic peptide (ANP) (103-125), 1 micrograms kg-1 min-1

Comparator

Normotensive Wistar Kyoto (WKY) control rats receiving the same infusion

Outcome

Central haemodynamic parameters and cardiac performance (including Mean Arterial blood pressure, Heart rate, cardiac output, total peripheral resistance, central blood volume, stroke volume, Left ventricular end diastolic pressure, cardiac contractility, and central venous pressure)surrogate

Atrial natriuretic peptide reduces blood pressure in normotensive rats primarily via reduced cardiac output, whereas in hypertensive rats it also reduces total peripheral resistance.

Cite This Study

Pettersson et al. (1988) studied Hypertension. rat ANP (103-125) vs. Normotensive Wistar Kyoto (WKY) control rats was evaluated on Mean Arterial blood pressure (MAP). Atrial natriuretic peptide infusion decreased mean arterial blood pressure by approximately 10% in both spontaneously hypertensive and normotensive rats.

synapsesocial.com/papers/6aacbc1d5e675567893a63dc https://doi.org/10.1111/j.1748-1716.1988.tb08485.x

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Differential haemodynamic effects of atrial natriuretic peptide (ANP) in normotensive and spontaneously hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differential haemodynamic effects of atrial natriuretic peptide (ANP) in normotensive and spontaneously hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider