ANP and Bradycardic Reflexes in Hypertensive Rats
Population
Spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY), n=40
Comparison
Perindopril for 6 weeks or 9 weeks, followed by… vs Untreated SHR and untreated WKY rats, with…
Design
Preclinical
Authors
Discussion
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Implication
Cardiac hypertrophy may blunt ANP reflex effects in hypertension; leaves open whether its reversal restores cardioprotection.
Structured PICO
P
Population
Spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY), n=40
I
Intervention
Perindopril (3 mg/kg per day) for 6 weeks (SHR-S) or 9 weeks (SHR-L), followed by alpha-rat ANP (150 ng/kg per minute IV) infusion
C
Comparator
Untreated SHR and untreated WKY rats, with saline vehicle infusion
O
Outcome
Heart rate reflexes to rapid intravenous infusions of methoxamine (cardiac baroreflex) and serotonin (von Bezold-Jarisch cardiac chemosensitive reflex)surrogate
Hypertension-induced cardiac hypertrophy, rather than hypertension itself, appears to inhibit the cardioprotective action of ANP through cardiac vagal reflexes in a rat model.
Cite This Study
Thomas et al. (1998) studied this question.