Why the study?
Does microinjection of ANP into the caudal nucleus tractus solitarii modulate arterial baroreflex-mediated control of sympathetic nervous system activity in spontaneously hypertensive rats?
Population
9-week-old, male spontaneously hypertensive rats and normotensive Wistar-Kyoto control rats
Comparison
Microinjection of ANP or monoclonal antibody to… vs Control microinjections of vehicle or mouse IgG
Design
Preclinical
Authors
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Hypothesis-generating in SHR models; leaves open any role for central ANP modulation in human hypertension.
Does microinjection of ANP into the caudal nucleus tractus solitarii modulate arterial baroreflex-mediated control of sympathetic nervous system activity in spontaneously hypertensive rats?
Endogenous ANP in the caudal nucleus tractus solitarii may contribute to the development or maintenance of hypertension in spontaneously hypertensive rats by blunting baroreflex-mediated control of sympathetic nervous system activity.
Zhu et al. (1996) studied this question.
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