Why the study?
Does blockade of endogenous ANP with a monoclonal antibody in the anterior hypothalamus reduce blood pressure and heart rate in spontaneously hypertensive rats?
Population
25 rats at 9 weeks of age.
Comparison
Microinjection of purified monoclonal antibody… vs Microinjection of control mouse IgG in 200 nl…
Design
Preclinical, Rats were randomly injected with two doses of MAb KY-ANP-II or…
Follow-up
60 minutes post-injection
Authors
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Suggests hypothalamic ANP involvement in SHR hypertension; leaves open whether central blockade merits human investigation.
Does blockade of endogenous ANP with a monoclonal antibody in the anterior hypothalamus reduce blood pressure and heart rate in spontaneously hypertensive rats?
Blockade of endogenous ANP in the anterior hypothalamus lowers blood pressure and heart rate in spontaneously hypertensive rats, suggesting its involvement in central blood pressure regulation.
Yang et al. (1990) studied this question.
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