Population
Conscious normotensive Sprague-Dawley rats, 1-yr-old conscious normotensive Wistar-Kyoto rats, and…
Comparison
i.v. infusion of ANP, CNP, or bolus… vs Basal conditions and acute volume expansion…
Design
Preclinical
Key result
Intravenous infusion of ANP blocked the plasma immunoreactive NT-ANP response to volume load (P < 0.001), showing that endogenous ANP directly modulates its own release via ANPA receptors.
Authors
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ANP autoregulation findings in animals warrant clinical caution; leaves open its role in human hypertension pending prospective data.
p-value: p=<0.001
Endogenous ANP directly modulates its own release via ANPA receptors in vivo, and this modulation of acute volume expansion-induced atrial peptide release appears to be altered in experimental hypertension.
Leskinen et al. (1997) studied Experimental hypertension. ANP, CNP, and HS-142-1 vs. Basal conditions and CNP was evaluated on Plasma levels of N-terminal fragment of pro-ANP (NT-ANP) and IR-ANP (p=<0.001). Intravenous infusion of ANP blocked the plasma immunoreactive NT-ANP response to volume load (P < 0.001), showing that endogenous ANP directly modulates its own release via ANPA receptors.