What does this research mean for the field?

Adult spontaneously hypertensive rats exhibit significantly reduced cardiac content and plasma concentrations of atrial natriuretic polypeptide compared to normotensive controls, showing an inverse correlation with blood pressure. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1985Japanese Circulation Journal-english EditionOpen Access

Cardiac content and plasma concentration of atrial natriuretic polypeptide (ANP) in spontaneously hypertensive rats (SHR).

Q: What are the key findings of this study?

Adult spontaneously hypertensive rats had significantly lower cardiac and plasma atrial natriuretic polypeptide levels compared to normotensive controls (p<0.01).

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Hypertension. Intervention: Spontaneous hypertension (SHR and SHR-SP strains) vs. Normotensive Wistar-Kyoto rats (WKY). Primary outcome: Cardiac ANP content and plasma ANP concentration (p=<0.01).

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Key result

Adult spontaneously hypertensive rats have lower cardiac and plasma ANP levels versus normotensive controls.

P<0.01

Why the study?

The relationship between cardiac and plasma atrial natriuretic polypeptide content and hypertension in genetic hypertensive rats was unclear.

Population

Young and adult spontaneously hypertensive rats, stroke-prone SHR, and normotensive Wistar-Kyoto rats

Comparison

Hypertensive rats (SHR and SHR-SP) vs normotensive control rats (WKY)

Design

Observational study using radioimmunoassay for ANP

Authors

THToshinobu HigaNational Hospital Organization Miyazaki Higashi Hospital KKKazuo KitamuraNippon Dental University AMAtsuro MiyataKagoshima University

Discussion

Member takes

Implication

Preclinical ANP isoform data in hypertensive rats should not guide care; leaves open human translation.

Study Design

Type

Observational

PICO

Population

Young and adult spontaneously hypertensive rats, stroke-prone SHR, and normotensive control Wistar-Kyoto rats.

Exposure / Comparator

Spontaneous hypertension (SHR and SHR-SP strains) vs Normotensive Wistar-Kyoto rats (WKY)

Primary Outcome

Cardiac ANP content and plasma ANP concentration, p=<0.01

Main Result

p-value: p=<0.01

Cite This Study

Higa et al. (1985) conducted an observational in Hypertension. Spontaneous hypertension (SHR and SHR-SP strains) vs. Normotensive Wistar-Kyoto rats (WKY) was evaluated on Cardiac ANP content and plasma ANP concentration (p=<0.01). Adult spontaneously hypertensive rats had significantly lower cardiac and plasma atrial natriuretic polypeptide levels compared to normotensive controls (p<0.01).

synapsesocial.com/papers/6aaf70b44687f6dd6a76eef8 https://doi.org/10.1253/jcj.49.973

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Cardiac content and plasma concentration of atrial natriuretic polypeptide (ANP) in spontaneously hypertensive rats (SHR).

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Cite This Study

Cardiac content and plasma concentration of atrial natriuretic polypeptide (ANP) in spontaneously hypertensive rats (SHR).

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Cite This Study

Also Consider

Also Consider