Key result
Acute volume expansion and salt loading similarly increase ir-ANP levels in rats independent of BP.
Why the study?
The effects of acute volume expansion and acute salt loading on plasma levels of atrial natriuretic peptides in hypertensive versus normotensive rats were unclear.
Population
Conscious adult (16 weeks) Wistar-Kyoto and spontaneously hypertensive rats
Comparison
Acute volume expansion and acute salt loading vs basal conditions in SHR and WKY rats
Design
Preclinical experimental study in conscious rats
Authors
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Hypertension does not alter ANP response to volume/salt load in rats; leaves open translational relevance to human volume regulation.
Chronic hypertension in spontaneously hypertensive rats does not alter basal or volume/salt-stimulated levels of circulating atrial natriuretic peptides compared to normotensive rats.
Haass et al. (1986) studied Hypertension. Acute volume expansion and acute salt loading vs. Basal state / Normotensive WKY rats was evaluated on Plasma levels of immunoreactive atrial natriuretic peptides (ir-ANP's). Acute volume expansion and acute salt loading similarly increased plasma concentrations of ir-ANP's in spontaneously hypertensive and normotensive rats, independent of blood pressure.
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