What question did this study set out to answer?

The aim was to investigate the vascular receptors for atrial natriuretic factor in spontaneously hypertensive rats and the differences across strains and ages.

September 1, 1992Cardiovascular Research

Vascular atrial natriuretic factor receptors in spontaneously hypertensive rats

Q: What does this research mean for the field?

Young spontaneously hypertensive rats exhibit increased vascular sensitivity and guanylate cyclase activity in response to atrial natriuretic factor, which normalizes with age and may contribute to their inability to counteract increased vasoconstriction later in life. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Population

Spontaneously hypertensive rats (SHR), Wistar-Kyoto (WKY), and Wistar rats (WR) at different ages

Comparison

Atrial natriuretic factor (ANF) vs Normotensive rats and different age groups

Design

Preclinical

Authors

ESErnesto L. SchiffrinMedical Council of Canada APAngèle ParentUniversity of Chicago JLJ. S. Louis

Discussion

Member takes

Implication

May indicate compensatory ANF signaling in early hypertension models; leaves open translational relevance to human disease.

Key Points

The aim was to investigate the vascular receptors for atrial natriuretic factor in spontaneously hypertensive rats and the differences across strains and ages.
Investigated relaxation and guanylate cyclase responses of blood vessels to ANF.
Analyzed binding of 125I-ANF to vascular membranes using SDS-PAGE after solubilization.
Compared responses across spontaneously hypertensive rats, Wistar-Kyoto, and Wistar rats at different ages.
Increased sensitivity to ANF in four-week-old SHR compared to WKY (pD2 = 8.9 vs. 8.5, p < 0.05).
Greater cyclic GMP production in mesenteric arteries of SHR at four weeks (p < 0.05) but similar in older rats.
Lower density of ANF binding sites in four-week-old SHR, which increased to similar levels as WKY by 12 weeks (p < 0.01).

Structured PICO

Population

Spontaneously hypertensive rats (SHR), Wistar-Kyoto (WKY), and Wistar rats (WR) at different ages

Intervention

Atrial natriuretic factor (ANF)

Comparator

Normotensive rats (WKY, WR) and different age groups

Outcome

Vascular relaxation, guanylate cyclase responses, binding of 125I-ANF to vascular membranes, and ANF receptor subtypessurrogate

Young spontaneously hypertensive rats exhibit increased vascular sensitivity to atrial natriuretic factor, which normalizes with age and may contribute to the maintenance of hypertension.

Cite This Study

Schiffrin et al. (1992) studied this question.

synapsesocial.com/papers/6a1bd1876f692abb725eea35 https://doi.org/10.1093/cvr/26.9.857

Topics

Hypertension management

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Vascular atrial natriuretic factor receptors in spontaneously hypertensive rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Vascular atrial natriuretic factor receptors in spontaneously hypertensive rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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