Key result
Intravenous or intracerebroventricular administration of alpha-hANP did not alter arterial pressure and renal nerve responses to graded electrical stimulation of aortic depressor nerves in rabbits.
Why the study?
Does alpha-hANP alter arterial baroreceptor control of sympathetic nerve activity by acting on the central nervous system in rabbits?
Does alpha-hANP alter arterial baroreceptor control of sympathetic nerve activity by acting on the central nervous system in rabbits?
Alpha-hANP does not modulate control of renal sympathetic nerve activity by acting on the central nervous system in a rabbit model.
Answers are grounded in this paper and cite their sources.
Alpha-hANP does not centrally modulate baroreflex control of renal sympathetic activity in rabbits; leaves open effects in other species or models.
This study aimed to examine whether atrial natriuretic peptide (ANP) alters arterial baroreceptor control of sympathetic nerve activity (SNA) by acting on the central nervous system (CNS). In rabbits anesthetized with alpha-chloralose, we examined changes in arterial pressure and renal SNA in response to graded electrical stimulation (1.7, 3.3, 5.0 Hz) of aortic depressor nerves during the intravenous (IV) infusion of saline or alpha-human atrial natriuretic peptide (alpha-hANP) (0.1, 1.0 microgram/kg/min) or after the intracerebroventricular (ICV) injections of saline or alpha-hANP (3, 10 micrograms). Sinoaortic denervation and bilateral vagotomy were done before examination in all rabbits to eliminate the influence of the known effects of ANP on arterial and cardiac receptors. IV alpha-hANP decreased arterial pressure but did not alter renal SNA. ICV alpha-hANP did not change arterial pressure or renal SNA. Arterial pressure and renal nerve responses to graded electrical stimulation of aortic depressor nerves were not altered by IV or ICV alpha-hANP. These results suggest that alpha-hANP does not modulate control of renal SNA by acting on CNS.
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Suzuki et al. (1988) studied this question. alpha-human atrial natriuretic peptide (alpha-hANP) vs. saline was evaluated on Changes in arterial pressure and renal sympathetic nerve activity in response to graded electrical stimulation of aortic depressor nerves. Intravenous or intracerebroventricular administration of alpha-hANP did not alter arterial pressure and renal nerve responses to graded electrical stimulation of aortic depressor nerves in rabbits.
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