Why the study?
Does intra-arterial infusion of atrial natriuretic factor attenuate vasoconstrictor responses to sympathetic nerve stimulation or norepinephrine in chloralose-anesthetized rabbits?
Does intra-arterial infusion of atrial natriuretic factor attenuate vasoconstrictor responses to sympathetic nerve stimulation or norepinephrine in chloralose-anesthetized rabbits?
Atrial natriuretic factor attenuates sympathetic nervous system mediated changes in vascular resistance at the neuroeffector site in a rabbit model.
No immediate clinical implications; extends preclinical evidence of ANF sympathetic modulation at the neuroeffector site in rabbits.
To determine whether atrial natriuretic factor (ANF) affects vasoconstrictor responses to electrical stimulation of sympathetic nerves or intra-arterial norepinephrine (NE), changes in perfusion pressure were measured during lumbar sympathetic nerve stimulation (LSNS, 1-8 Hz), or administration of NE (50-200 ng), in an isolated constant flow-perfused hindlimb of chloralose-anesthetized rabbit before and after intra-arterial infusion of ANF (0.5 ng.mL-1.min-1). ANF significantly attenuated responses to LSNS (relative potency, RP = 0.65) and to NE (RP = 0.47). We conclude that ANF attenuates vasoconstrictor responses to both LSNS and NE. Thus ANF alters sympathetic nervous system mediated changes in vascular resistance possibly at the neuroeffector site.
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Kaushik P. Patel (1989) studied this question.
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