Key result
Atrial natriuretic factor elicited direct vasoconstriction in conscious dogs, both direct and reflexly mediated vasoconstriction in rats, and primarily reflexly mediated vasoconstriction in monkeys.
Why the study?
Does atrial natriuretic factor infusion alter mean arterial pressure, cardiac output, and total peripheral resistance in conscious dogs, rats, and monkeys?
Population
Conscious dogs (n=19, including intact and denervated models), rats (n=6 intact), and monkeys (n=6 intact)
Comparison
30-minute infusions of atrial natriuretic factor… vs Baseline measurements and responses before vs…
Design
Preclinical
Follow-up
30 minutes
Authors
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Species differences in ANF vasoconstriction urge caution extrapolating animal data; leaves open human vascular effects.
Does atrial natriuretic factor infusion alter mean arterial pressure, cardiac output, and total peripheral resistance in conscious dogs, rats, and monkeys?
Atrial natriuretic factor elicits direct vasoconstriction in dogs and rats, but primarily reflexly mediated vasoconstriction in monkeys, demonstrating fundamental species differences in its vascular actions.
Shen et al. (1990) studied Healthy animals (n=31). Atrial natriuretic factor (ANF) vs. Baseline / before and after ganglionic blockade was evaluated on Mean arterial pressure, cardiac output, and total peripheral resistance. Atrial natriuretic factor elicited direct vasoconstriction in conscious dogs, both direct and reflexly mediated vasoconstriction in rats, and primarily reflexly mediated vasoconstriction in monkeys.
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