October 1, 1990AJP Regulatory Integrative and Comparative Physiology
Atrial natriuretic peptide infusion causes vasoconstriction after autonomic blockade in conscious dogs
Why the study?
Does alpha-human ANP infusion cause vasoconstriction independent of autonomic reflexes in conscious dogs?
Population
Conscious, trained, chronically instrumented dogs (n=7)
Comparison
30-min infusions of alpha-human atrial… vs Responses in the absence of autonomic nervous…
Design
Preclinical
Follow-up
30 minutes
Authors
Discussion
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Member takes
Implication
ANP may exert direct vasoconstriction independent of reflexes in dogs; leaves open translation to human physiology or therapy.
Structured PICO
Does alpha-human ANP infusion cause vasoconstriction independent of autonomic reflexes in conscious dogs?
P
Population
Conscious, trained, chronically instrumented dogs (n=7)
I
Intervention
30-min infusions of alpha-human atrial natriuretic peptide (alpha hANP; 25, 50, and 100 ng.kg-1.min-1) in the presence and absence of autonomic nervous system blockade using pentolinium
C
Comparator
Responses in the absence of autonomic nervous system blockade
O
Outcome
Hemodynamic and renal excretory responses (mean arterial pressure, cardiac output, total peripheral resistance, renal vascular resistance, mesenteric vascular resistance)surrogate
Atrial natriuretic peptide causes vasoconstriction in mesenteric and other nonrenal vascular beds independent of autonomic reflexes in conscious dogs.
Cite This Study
Woods et al. (1990) studied this question.