Why the study?
Does atrial natriuretic peptide reverse angiotensin II-induced venoconstriction in ganglion-blocked dogs?
Population
6 ganglion-blocked dogs with angiotensin II-induced hypertension
Comparison
Atrial natriuretic peptide infusion vs Angiotensin II alone
Design
Preclinical
Authors
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ANP selectively reverses experimental venoconstriction; leaves open translation to human vasoconstriction states.
Does atrial natriuretic peptide reverse angiotensin II-induced venoconstriction in ganglion-blocked dogs?
Atrial natriuretic peptide reverses angiotensin II-induced venoconstriction but not arterial vasoconstriction, indicating their interaction occurs primarily in the venous circulation.
Lee et al. (1989) studied this question.
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