Key result
Long-term increases in circulating levels of ANP had no significant effect on arterial pressure (125 vs 133 mmHg) in dogs with angiotensin II-induced hypertension.
Why the study?
Does ANP infusion reduce arterial pressure in conscious dogs with angiotensin II-induced hypertension?
Population
Conscious dogs (n=9) with angiotensin II-induced hypertension
Comparison
ANP103-126 infused at a rate of 20 ng.kg-1.min-1… vs Angiotensin II infusion alone
Design
Preclinical
Follow-up
7 days
Authors
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Does not support ANP as antihypertensive in angiotensin II hypertension; leaves open effects in other models or species.
Does ANP infusion reduce arterial pressure in conscious dogs with angiotensin II-induced hypertension?
Absolute Event Rate: 125% vs 133%
Physiological increases in plasma ANP do not exhibit long-term antagonistic effects toward the vasoconstrictor actions of angiotensin II in a canine model.
Granger et al. (1990) studied Angiotensin II-induced hypertension (n=9). ANP103-126 vs. ANG II infusion alone (baseline) was evaluated on Arterial pressure. Long-term increases in circulating levels of ANP had no significant effect on arterial pressure (125 vs 133 mmHg) in dogs with angiotensin II-induced hypertension.
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