Key result
ANP prevents GFR reduction and attenuates angiotensin II-induced antinatriuresis in preclinical models.
Why the study?
The inhibitory effects of atrial natriuretic peptide on angiotensin II-induced renal responses needed to be examined.
Does atrial natriuretic peptide attenuate angiotensin II-induced reductions in glomerular filtration rate and urinary sodium excretion in anesthetized dogs?
Does atrial natriuretic peptide attenuate angiotensin II-induced reductions in glomerular filtration rate and urinary sodium excretion in anesthetized dogs?
Answers are grounded in this paper and cite their sources.
In anesthetized dogs, atrial natriuretic peptide attenuates angiotensin II-induced antinatriuresis primarily by preventing hypofiltration (reduction in glomerular filtration rate) rather than altering fractional sodium excretion.
Inhibitory effects of atrial natriuretic peptide (ANP) on angiotensin II (ANG II)-induced renal responses were examined in anesthetized dogs. ANG II (5 ng/kg per min) was infused intravenously and changes in renal hemodynamics and urine formation were compared between the ANP (10 ng/kg per min)-infused kidney and the contralateral vehicle-infused (control) kidney. ANG II reduced absolute and fractional urinary sodium excretion in both the ANP-infused kidney and the control kidney. ANG II also reduced glomerular filtration rate in the control kidney but not in the ANP-infused kidney. The ANG II-induced reduction in urinary sodium excretion in the ANP-infused kidney was smaller than the response in the control kidney, whereas ANP did not affect the reduction in fractional sodium excretion. These results suggest that ANP prevents hypofiltration and thereby attenuates the antinatriuresis induced by ANG II.
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Tomura et al. (1995) studied Angiotensin II-induced antinatriuresis. Atrial natriuretic peptide (ANP) vs. Contralateral vehicle-infused (control) kidney was evaluated on Renal hemodynamics (glomerular filtration rate) and urinary sodium excretion (absolute and fractional). Atrial natriuretic peptide (10 ng/kg/min) prevented glomerular filtration rate reduction and attenuated antinatriuresis induced by angiotensin II (5 ng/kg/min) in anesthetized dogs.
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