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March 1, 1988AJP Regulatory Integrative and Comparative Physiology

Renal response to atrial natriuretic factor is modulated by intrarenal angiotensin II

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Why the study?

Does intrarenal angiotensin II attenuate the natriuretic response to atrial natriuretic factor in anesthetized dogs?

Population

Anesthetized dogs (n=8)

Comparison

Systemically administered atrial natriuretic… vs Systemically administered ANF with saline…

Design

Preclinical

Authors

CSC. J. ShowalterMayo ClinicRZR. S. ZimmermanMayo ClinicTST. R. SchwabMayo Clinic

Discussion

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Implication

May modulate ANF natriuresis via intrarenal ANG II in dogs; leaves open relevance to human volume regulation.

Key Points

  • To determine whether intrarenal angiotensin II attenuates the increases in urinary sodium excretion and renal hemodynamic responses induced by systemic atrial natriuretic factor.
  • Assessed 8 anesthetized dogs administered systemic infusions of atrial natriuretic factor at 0.3 micrograms.kg-1.min-1.
  • Infused a nonpressor dose of angiotensin II (1.5 ng.kg-1.min-1) into the left kidney while infusing saline into the right kidney as a control.
  • Angiotensin II infusion attenuated increases in urinary sodium excretion (delta +160.8 ± 44.7 vs. delta +369.4 ± 56.9 mu eq/min, P < 0.005) and fractional sodium excretion (delta +2.55 ± 0.62 vs. delta +4.26 ± 0.82%, P < 0.03) relative to the control kidney.
  • Glomerular filtration rate increased solely in the control kidney, while urine osmolality decreased in both kidneys.

Structured PICO

Does intrarenal angiotensin II attenuate the natriuretic response to atrial natriuretic factor in anesthetized dogs?

P
Population
Anesthetized dogs (n=8)
I
Intervention
Systemically administered atrial natriuretic factor (ANF) (0.3 micrograms.kg-1.min-1) with angiotensin II (ANG II) infusion into the left kidney at a nonpressor dose (1.5 ng.kg-1.min-1)
C
Comparator
Systemically administered ANF with saline infusion into the right kidney
O
Outcome
Urinary sodium excretion and fractional sodium excretionsurrogate

Intrarenal angiotensin II attenuates the natriuretic response to atrial natriuretic factor, which is associated with a blunted increase in glomerular filtration rate.

Cite This Study

Showalter et al. (1988) studied this question.

synapsesocial.com/papers/6a1ec4adbf2a5d44faaf4beehttps://doi.org/10.1152/ajpregu.1988.254.3.r453
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationship between renal hemodynamic and natriuretic effects of atrial natriuretic factor1986 · 107 citations
  2. 2Angiotensin II-induced atrial natriuretic factor release in dogs is not related to hemodynamic responses.1990 · 23 citations
  3. 3Effects of synthetic atrial natriuretic factor on renal function and renin release1984 · 535 citations
  4. 4Effect of atrial natriuretic factor on renal hemodynamics in the rat1986 · 29 citations
  5. 5Possible modulatory role of angiotensin II on atrial peptide-induced natriuresis1987 · 14 citations