What does this research mean for the field?

The natriuretic response to atrial natriuretic peptide depends on the baseline state of the renin-angiotensin system, as profound hypotension induced by ACE inhibition abolishes the natriuretic effect, which can be restored by angiotensin II. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research examines how atrial natriuretic peptide affects kidney functions when the renin-angiotensin system is controlled.

March 1, 1988Circulation ResearchOpen Access

Renal effects of atrial natriuretic factor during control of the renin-angiotensin system in anesthetized dogs.

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Why the study?

Does atrial natriuretic peptide affect fractional sodium excretion and hemodynamics during renin-angiotensin system blockade in anesthetized dogs?

Population

One-kidney anesthetized dogs

Comparison

Intrarenal infusions of 1, 5, 25, and 125… vs Vehicle-treated dogs

Design

Preclinical

Authors

ASAndrea A. SeymourMerck & Co., Inc., Rahway, NJ, USA (United States)EME K MazackUnited States Military Academy

Discussion

Member takes

Implication

ANP natriuresis may require Ang II during ACE inhibition; leaves open relevance in patients on RAAS blockade.

Key Points

This research examines how atrial natriuretic peptide affects kidney functions when the renin-angiotensin system is controlled.
Intrarenal infusions of synthetic atrial natriuretic peptide at varying doses were administered.
Effects on sodium excretion, blood pressure, and plasma renin activity were measured in anesthetized one-kidney dogs.
Enalaprilat was used to block the renin-angiotensin system and its effects on renal responses were assessed.
Atrial natriuretic peptide increased fractional sodium excretion to a peak of 5.1% at 25 pmol/kg/min infusion.
Inhibition of the renin-angiotensin system with enalaprilat reduced baseline blood pressure to 86 mm Hg without impacting sodium excretion from atrial natriuretic peptide.
Infusion of angiotensin II restored blood pressure and enhanced the natriuretic response to atrial natriuretic peptide.

Structured PICO

Does atrial natriuretic peptide affect fractional sodium excretion and hemodynamics during renin-angiotensin system blockade in anesthetized dogs?

Population

One-kidney anesthetized dogs

Intervention

Intrarenal infusions of 1, 5, 25, and 125 pmol/kg/min synthetic rat atrial natriuretic peptide 101-126, with or without enalaprilat (3 mg/kg i.v.) and angiotensin II (2.5 ng/kg/min)

Comparator

Vehicle-treated dogs

Outcome

Fractional sodium excretionsurrogate

Cite This Study

Seymour et al. (1988) studied this question.

synapsesocial.com/papers/6a1bd1876f692abb725eea45 https://doi.org/10.1161/01.res.62.3.506

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Renal effects of atrial natriuretic factor during control of the renin-angiotensin system in anesthetized dogs.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Renal effects of atrial natriuretic factor during control of the renin-angiotensin system in anesthetized dogs.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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